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VERSION:2.0
X-WR-CALNAME:Fumarate hydratase loss as a paradigm of oncometabolism
METHOD:PUBLISH

BEGIN:VEVENT
UID:7181
LOCATION:Kussmaulallee 12 91054 Erlangen
SUMMARY:Fumarate hydratase loss as a paradigm of oncometabolism
DESCRIPTION:\n\nSeminar series TRR 305 – Striking a moving target: From mechanisms of metastatic organ colonisation to novel systemic therapies\n\nSpeaker: Dr. Christian Frezza (University of Cologne, CECAD, Cologne \n\nUniversity of Cambridge, MRC Cancer Unit, Cambridge)\n\nThe role of mitochondrial dysfunction in cancer has been debated for over a century. Recent bioinformatic data analyses revealed that mitochondrial genes are suppressed in cancer with poor clinical outcome. Furthermore, the fact that mutations of core metabolic enzymes in the mitochondria such as Fumarate Hydratase (FH) cause renal cancer strongly indicates that mitochondrial dysfunction can drive cancer. Today, I will provide an overview of our recent findings about the molecular mechanisms through which mitochondrial dysfunction can drive transformation. In particular, using a novel genetically modified mouse model, I will show that FH loss has different outcomes in different tissues, and whilst kidneys are very robust to FH loss, other tissues don’t tolerate FH loss and here FH-deficient cells are negatively selected. Our work provides some insights into potential mechanisms of tissue-specific tumorigenesis based on metabolic permissiveness.\n\nZoom-Meeting-Link\n\nMeeting-ID: 672 2119 5153 Code: 721518
CLASS:PUBLIC
DTSTART:20230118T140000Z
DTEND:20230118T160000Z
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