Metabolic rewiring is a hallmark of cancer cells. However, how nutrients drive the ability of cancer cells to rewire their metabolism is poorly defined. We are investigating the in vivo nutrient metabolism during metastasis formation to mechanistically understand how nutrients from the microenvironment enable cancers to progress from a local to a systemic disease. Using 13C tracer infusions in mouse models we find that nutrient availability shapes the metabolism and phenotype of cells and subsequently promotes the progression of cancer. Consequently, interfering with nutrient metabolism emerges as a promising therapeutic strategy against cancer. Taken together, our research highlights that nutrient metabolism is an important driver of cancer progression.

Dr. Sarah-Maria Fendt
Lab of Cellular Metabolism and Metabolic Regulation
VIB-KU Leuven Center for Cancer Biology (CCB) Belgium

Zoom-Meeting-Link
https://uni-regensburg.zoom.us/j/68524772498?pwd=Yk9ibmltekk3VmJPTmpLOXdBZjdzUT09
Meeting-ID: 685 2477 2498
Code: 619702