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Abteilung für Molekulare Pneumologie

Molekulare Pneumologie


Prof. Dr.Dr.Ph.D. Susetta Neurath-Finotto

Überblick Forschungsinhalte

The recognition and elimination of tumor cells by the immune system requires cytotoxic effector functions that are mediated by CD4+ Th1 cells and CD8+ cytotoxic T cells (CTLs), which are inhibited in lung cancer patients. Aim of our group is to set up new immunotherapies to further improve the current effects of the immune checkpoint receptor inhibitors like anti-PD-1 (programmed cell death protein 1) antibodies. PD-1 desensitizes T cell receptor (TCR)-mediated signals and contributes to T cell exhaustion, a state of T cell dysfunction promoting tumour cell growth. In addition, clinical responses to current immunotherapy vary considerably and many patients underlining the need to better understand fundamental molecular mechanisms of this pathway and its role in anti-tumoral immunity. Moreover, a preventive anti-cancer intervention through regulation of the nutrition of the patients with lung cancer is gaining much attention. We recently demonstrated that reducing dietary carbohydrate intake might affect tumor growth and improve current immunotherapy, and target tumor immune escape caused by glucose levels in the tumor microenvironment.

Laufende Forschungsprojekte

  • The role of the Transcription factor PU1 in NSCLC (DFG Grant)
  • Role of IL-2/IL-2 receptor in NSCLC (Sander Stiftung Grant)
  • Role of Blimp-1 in NSCLC
  • The role of Glucose in the immunoresponse to NSCLC
  • The role of lipids in NSCLC
  • The immunoregulation of Fiber rich microenvironmentin NSCLC.


Development of new immunotherapy for Non-small Cell Lung cancer



  • Professor, Dr. Daniel Christ, St Vincent's Clinical School, Faculty of Medicine, UNSW, Sydney.
  • Prof. Dr. med. Veronika Sexl, University of Veterinary Medicine, Vienna

FAU-Uniklinikum Erlangen: 

I. Medical Clinic:

  • Prof. Dr. med. Markus F. Neurath
  • Dr. Dentist Mircea T. Chiriac

Department of Thoracic Surgery: 

  • Prof. Dr. med. Horia Sirbu
  • Dr. med. Denis Trufa

Institut of Pathology

  • Prof. Dr. med. Arndt Hartmann
  • PD Dr. med. Carol Geppert
  • Prof. Dr. med. Ralf J. Rieker



Department of Molecular Pneumology
Hartmannstrasse 14
91052 Erlangen


09131 85-35883

Weiterführende Links



Stand: 03/2023